Maguchi M, Kohara K, Okura T, Li S, Takezaki M, Nishida W, Hiwada K
2nd Department of Internal Medicine, Ehime University School of Medicine, Japan.
Angiology. 1996 Jul;47(7):643-8. doi: 10.1177/000331979604700702.
Association between angiotensin-converting enzyme (ACE) gene polymorphism and essential hypertension in a Japanese population with the same socioeconomic background was investigated. Insertion-deletion (I/D) polymorphism of the ACE gene located on intron 16 was detected by polymerase chain reaction. Association between ACE gene polymorphism and family history of essential hypertension as well as the development of vascular damage in eye fundi were also investigated. Variation at ACE loci did not contribute to essential hypertension and the vascular damages in eye fundi. These results suggest that the ACE gene was not directly responsible for essential hypertension in this particular Japanese population with the same socioeconomic background.
在具有相同社会经济背景的日本人群中，研究了血管紧张素转换酶（ACE）基因多态性与原发性高血压之间的关联。通过聚合酶链反应检测位于第16内含子上的ACE基因的插入/缺失（I/D）多态性。还研究了ACE基因多态性与原发性高血压家族史以及眼底血管损伤发展之间的关联。ACE基因座的变异对原发性高血压和眼底血管损伤没有影响。这些结果表明，在这一具有相同社会经济背景的特定日本人群中，ACE基因并非直接导致原发性高血压的原因。
