Myasnikova E M, Rachev S T, Yakovlev A Y
Department of Applied Mathematics, St. Petersburg State Technical University, Russia.
Math Biosci. 1996 Jul 1;135(1):85-109. doi: 10.1016/0025-5564(95)00173-5.
Some of the ideas arising in queueing theory are applied to describe the repair mechanisms responsible for recovery of cells from potentially lethal radiation damage. Two alternative versions are presented of a queueing model of damage repair after a single dose of irradiation. The first version represents a linear misrepair model, and the second invokes the idea of spontaneous lesion fixation. They are pieced together in the third model, allowing for both mechanisms. The consistency of the proposed models with published experimental data is tested.
排队论中产生的一些观点被应用于描述负责细胞从潜在致死性辐射损伤中恢复的修复机制。针对单次辐照后的损伤修复排队模型，提出了两种不同版本。第一个版本代表线性错配修复模型，第二个版本引入了自发损伤固定的概念。在第三个模型中将它们整合在一起，同时考虑了这两种机制。检验了所提出模型与已发表实验数据的一致性。
