Dixon J M, Dobie V, Lamb J, Walsh J S, Chetty U
Edinburgh Breast Unit, Western General Hospital, Edinburgh, UK.
Br J Surg. 1996 Feb;83(2):264-5.
A prospective study was performed in 202 patients with 219 fibroadenomas, diagnosed by a combination of clinical examination, ultrasonography and fine-needle aspiration cytology. Patients were given the choice of excision or conservative management with regular monitoring by ultrasonography. Sixteen patients with 18 fibroadenomas opted for excision and all 18 lesions were histologically confirmed as fibroadenomas. A further 152 patients with 163 fibroadenomas were observed for a minimum period of 2 years; 13 fibroadenomas increased significantly in size (all 13 were excised and confirmed histologically as fibroadenomas), 19 decreased significantly in size, 42 resolved and the remaining 89 showed no change in size. Conservative management of fibroadenomas in patients under the age of 40 is safe and acceptable to the majority of women.
对202例患有219个纤维腺瘤的患者进行了一项前瞻性研究,这些纤维腺瘤通过临床检查、超声检查和细针穿刺细胞学检查相结合的方式确诊。患者可选择切除或采用超声定期监测的保守治疗方法。16例患有18个纤维腺瘤的患者选择了切除,所有18个病变经组织学确诊为纤维腺瘤。另外152例患有163个纤维腺瘤的患者被观察了至少2年;13个纤维腺瘤大小显著增加(所有13个均被切除并经组织学确诊为纤维腺瘤),19个大小显著减小,42个消退,其余89个大小无变化。对40岁以下患者的纤维腺瘤进行保守治疗对大多数女性来说是安全且可接受的。