Widdison A L, Cunningham S
Department of Surgery, Frenchay Hospital, Bristol, UK.
Br J Surg. 1996 May;83(5):633-6. doi: 10.1002/bjs.1800830514.
Circulating lymphocyte numbers and activation together with granulocyte function were measured in 20 patients in the early stages of an attack of acute pancreatitis and in 20 healthy controls. Circulating lymphocytes, T lymphocytes, and CD4 and CD8 T lymphocyte subsets were decreased in both mild pancreatitis (67-80 per cent of controls) and severe pancreatitis (22-40 per cent of controls). CD4:CD8 ratios were unchanged and median (interquartile range) interleukin 2 receptor expression was increased from less than 1 per cent in controls to 14(6) per cent in severe pancreatitis, suggesting lymphocyte activation. Median granulocyte chemiluminescence was increased to 293 per cent of controls in severe pancreatitis and random motility was reduced to 77 per cent of controls, indicating increased metabolic activity. Complement-mediated antibody-independent opsonization and chemotaxis toward endotoxin were normal. Immune function is not reduced early in acute pancreatitis. Granulocyte hyperactivity may be important in the development of multiple organ failure.
对20例急性胰腺炎发作早期患者及20名健康对照者的循环淋巴细胞数量、活化情况以及粒细胞功能进行了检测。在轻度胰腺炎（为对照者的67% - 80%）和重度胰腺炎（为对照者的22% - 40%）中，循环淋巴细胞、T淋巴细胞以及CD4和CD8 T淋巴细胞亚群均减少。CD4:CD8比值未变，白细胞介素2受体表达的中位数（四分位间距）从对照者的不到1%增加至重度胰腺炎患者的14(6)%，提示淋巴细胞活化。重度胰腺炎时，粒细胞化学发光的中位数增加至对照者的293%，随机运动能力降低至对照者的77%，表明代谢活性增强。补体介导的非抗体依赖调理作用以及对内毒素的趋化作用正常。急性胰腺炎早期免疫功能并未降低。粒细胞功能亢进可能在多器官功能衰竭的发生中起重要作用。
