Sassone-Corsi P
Institut de Génétique et de Biologie Moléculaire et Cellulaire, C.U. de Strasbourg, France.
Annu Rev Cell Dev Biol. 1995;11:355-77. doi: 10.1146/annurev.cb.11.110195.002035.
In eukaryotes, transcriptional regulation upon stimulation of the adenylate cyclase signaling pathway is mediated by a family of cAMP-responsive nuclear factors. This family consists of a large number of members that may act as activators or repressors. These factors contain the basic domain/leucine zipper motifs and bind as dimers to cAMP-response elements (CRE). The function of CRE-binding proteins is modulated by phosphorylation by several kinases. The ICER (inducible cAMP early repressor) protein is the only inducible member of this family. The induction of this powerful repressor is likely to be important for the transient nature of cAMP-induced gene expression. CRE-binding proteins have been found to play an important role in the physiology of the pituitary gland, in regulating spermatogenesis, in the response to circadian rhythms, and in the molecular basis of memory.
在真核生物中，腺苷酸环化酶信号通路受刺激后的转录调控由一类cAMP反应性核因子介导。该家族由大量成员组成，这些成员可能作为激活剂或抑制剂发挥作用。这些因子含有碱性结构域/亮氨酸拉链基序，并以二聚体形式结合到cAMP反应元件（CRE）上。CRE结合蛋白的功能受几种激酶磷酸化的调节。ICER（诱导型cAMP早期阻遏物）蛋白是该家族唯一的诱导型成员。这种强大阻遏物的诱导可能对cAMP诱导的基因表达的短暂性很重要。已发现CRE结合蛋白在垂体生理、调节精子发生、对昼夜节律的反应以及记忆的分子基础中发挥重要作用。
