Della Fazia M A, Servillo G, Sassone-Corsi P
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS-Inserm, B.P. 163, Illkirch, Strasbourg, France.
FEBS Lett. 1997 Jun 23;410(1):22-4. doi: 10.1016/s0014-5793(97)00445-6.
In eukaryotes, transcriptional regulation upon stimulation of the adenylyl cyclase signalling pathway is mediated by a family of cAMP-responsive nuclear factors. This family consists of a large number of members which may act as activators or repressors. These factors contain the basic domain/leucine zipper motifs and bind as dimers to cAMP-response elements (CRE). The function of CRE-binding proteins (CREB) is modulated by phosphorylation by the cAMP-dependent protein kinase. The ICER (inducible cAMP early repressor) protein is the only inducible member of this family and is a product of the CREM gene. The induction of this powerful repressor is likely to be important for the transient nature of cAMP-induced gene expression. CREB proteins have been found to play an important role in the physiology of neuroendocrine functions. In addition, recent results indicate that CREB and CREM could be involved in the proliferation of hepatocytes which follows partial hepatectomy.
在真核生物中，腺苷酸环化酶信号通路受刺激后的转录调控由一类cAMP反应性核因子介导。该家族由大量成员组成，这些成员可能作为激活剂或抑制剂发挥作用。这些因子包含碱性结构域/亮氨酸拉链基序，并以二聚体形式与cAMP反应元件（CRE）结合。CRE结合蛋白（CREB）的功能通过cAMP依赖性蛋白激酶的磷酸化来调节。ICER（诱导型cAMP早期阻遏物）蛋白是该家族中唯一的诱导型成员，是CREM基因的产物。这种强大阻遏物的诱导可能对cAMP诱导的基因表达的短暂性很重要。已发现CREB蛋白在神经内分泌功能的生理学中起重要作用。此外，最近的结果表明，CREB和CREM可能参与部分肝切除术后肝细胞的增殖。
