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Experimental myocarditis in the guinea-pig.

作者信息

Radhakrishnan V V

机构信息

Department of Pathology, Sree Chitra Tirunal Institute for Medical Sciences & Technology, India.

出版信息

Cardiovasc Res. 1996 Apr;31(4):651-4.

PMID:8689658
Abstract

In guinea-pigs, myocarditis was induced under experimental conditions by immunizing the animals with rabbit skeletal muscle myosin-beta. The salient histopathological features were foci of perivascular lymphonononuclear aggregates, necrosis, and degeneration of myocardial cells. Antimyosin-beta antibodies in the immune complexes were demonstrated in the sera of the guinea-pigs. An immune-complex-mediated tissue-injury is proposed in the pathogenesis of myocarditis.

摘要

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