Weiter J, Fine B S
Am J Ophthalmol. 1977 May;83(5):741-50. doi: 10.1016/0002-9394(77)90143-x.
Light and electron microscopy studies of eyes removed from an 84-year-old man after death indicated a normal optic nerve despite severe peripapillary choroidal atrophy. In the area of atrophy, the choriocapillaris, retinal pigment epithelium, and photoreceptors were absent and there was a marked decrease in choroidal arteries and veins. Bruch's membrane was intact except for several breaks in the peripapillary region. Müller cells, in the region of atrophy, produced an aberrant, thick basement membrane either in the outer layers of the neurosensory retina or directly applied to Bruch's membrane. On the basis of this study, we postulate that the primary abnormality in this disease is of the choroidal vasculature.
对一名84岁男性死后摘除的眼睛进行的光镜和电镜研究表明，尽管存在严重的视乳头周围脉络膜萎缩，但视神经正常。在萎缩区域，脉络膜毛细血管、视网膜色素上皮和光感受器缺失，脉络膜动静脉明显减少。除视乳头周围区域有几处破裂外，布鲁赫膜完整。在萎缩区域，米勒细胞在神经感觉视网膜外层或直接附着于布鲁赫膜处产生异常增厚的基底膜。基于这项研究，我们推测该疾病的原发性异常在于脉络膜血管系统。
