Tseng L H, Lee T Y, Yang Y S, Ko T M, Chuang S M
Department of Medical Genetics, National Taiwan University Hospital, Taipei, Republic of China.
Contraception. 1996 Mar;53(3):177-80. doi: 10.1016/0010-7824(96)00007-8.
From November 1988 to December 1994, a total of 567 female volunteers were enrolled in Norplant implant studies at the National Taiwan University Hospital. After a median follow-up of 29 months, only 3 of the 529 available cases became pregnant (a cumulative rate of 1.2 pregnancies per 100 users over 5 years). Chromosome analysis of 2 of the 3 abortuses revealed 46,XX/46,XX,inv(3) and 46,XX. Menstrual problems were the most common adverse effects and were also the main reason for discontinuation (65%, 108/166). The continuation rate was 90%, 78%, 70%, 61%, and 42% at the end of 1, 2, 3, 4, and 5 years after insertion, respectively. In the 21 patients who wished to become pregnant, fertility recurred soon after removal of the Norplant implants. The data suggested that the Norplant implants system is a highly effective, safe, and long-acting method of reversible contraception. It would be worthwhile to introduce this contraceptive system to Taiwan's family planning program.
1988年11月至1994年12月，国立台湾大学医院共招募了567名女性志愿者参与左炔诺孕酮皮下埋植剂植入研究。在中位随访29个月后，529例可获得的病例中只有3例怀孕（5年期间每100名使用者的累积妊娠率为1.2次妊娠）。3例流产病例中的2例染色体分析显示为46,XX/46,XX,inv(3)和46,XX。月经问题是最常见的不良反应，也是停药的主要原因（65%，108/166）。植入后1、2、3、4和5年末的续用率分别为90%、78%、70%、61%和42%。在21名希望怀孕的患者中，取出左炔诺孕酮皮下埋植剂后很快恢复了生育能力。数据表明，左炔诺孕酮皮下埋植剂系统是一种高效、安全且长效的可逆避孕方法。将这种避孕系统引入台湾的计划生育项目是值得的。
