De Koninck G C, Hébert M, Carrier J, Lamarche C, Dufour S
School of Psychology, University of Ottawa, Ontario, Canada.
Electroencephalogr Clin Neurophysiol. 1996 Jan;98(1):42-50. doi: 10.1016/0013-4694(95)00215-4.
The time courses of slow wave sleep (SWS) and EEG slow wave activity (SWA) were examined in relation to core body temperature (CBT) during extended sleep periods of 15 h. Ten subjects (4 male, 6 female; aged 18-29 years) slept in the laboratory for 3 consecutive nights (2 of 8 h, and the last of 15 h). Bedtime was as close as possible to subjects' habitual bedtimes, but was always between 23.00 h and 1.00 h, and was the same on all nights. Standard polysomnographic measures as well as rectal temperature were collected continuously each night. Using 3 h blocks, SWS and SWA declined with time asleep, then showed a significant increase in the final 3 h. Using a more specific measure with 15 min means, 8 of the 10 subjects showed SWA returns late in sleep, that were not related to preceding amounts of waking after sleep onset (WASO), rapid eye movement sleep (REMS), or WASO+REMS. The timing and magnitude of the SWA return was significantly associated with the phase of CBT as indexed by delay from sleep onset to CBT minimum. The findings are consistent with a 12 h rhythm of SWS and SWA that is related to the phase of the CBT rhythm, with the minor pole of SWS/SWA occurring independently of WASO and/or REMS.
在长达15小时的延长睡眠时间内，研究了慢波睡眠（SWS）和脑电图慢波活动（SWA）的时间进程与核心体温（CBT）的关系。10名受试者（4名男性，6名女性；年龄18 - 29岁）在实验室连续睡3晚（前两晚8小时，最后一晚15小时）。就寝时间尽可能接近受试者的习惯就寝时间，但始终在23:00至1:00之间，且三晚相同。每晚持续收集标准多导睡眠图测量数据以及直肠温度。以3小时为时间段，SWS和SWA随睡眠时间下降，然后在最后3小时显著增加。采用更具体的15分钟均值测量方法，10名受试者中有8名在睡眠后期出现SWA回升，这与睡眠开始后的先前觉醒量（WASO）、快速眼动睡眠（REMS）或WASO + REMS无关。SWA回升的时间和幅度与CBT的相位显著相关，CBT相位以从睡眠开始到CBT最低点的延迟来衡量。这些发现与SWS和SWA的12小时节律一致，该节律与CBT节律的相位相关，SWS/SWA的小峰值独立于WASO和/或REMS出现。
