Wozniak E J, Kazacos K R, Telford S R, McLaughlin G L
Department of Veterinary Pathobiology, Purdue University, West Lafayette, IN 47907, USA.
Int J Parasitol. 1996 Feb;26(2):141-6. doi: 10.1016/0020-7519(95)00110-7.
Laboratory-reared Aedes aegypti mosquitoes were employed in the successful transmission of Hepatozoon mocassini from a cotton-mouth moccasin (Agkistrodon piscivorus leucostoma) to 3 lizard species (Sceloporus undulatus, Eumeces obsoletus and Sceloporus poinsetti). Marked to severe lethargy and anorexia developed in the S. undulatus, E. obsoletus and S. poinsetti at 15, 38, and 96 days postinfection (PI), respectively. All 3 lizards developed a leukocytosis and had increased plasma aspartate aminotransferase activity (AST) by 14 days PI. Multifocal random hepatocellular necrosis and intrahepatic aggregates of heterophils centered on mature H. mocassini meronts were demonstrated in all 3 lizards. The pulmonary interstitium was multifocally thickened by aggregates of heterophils centered on meronts. No comparable clinical or anatomical pathological changes were demonstrated in naturally infected snakes. The results of this study suggest that H. mocassini is capable of inducing necrotizing inflammatory by lesions in unnatural reptilian hosts.
实验室饲养的埃及伊蚊成功地将莫卡西尼肝簇虫从棉口蝮蛇（Agkistrodon piscivorus leucostoma）传播给了3种蜥蜴（变色蜥、德州石龙子和波因塞特变色蜥）。感染后15天、38天和96天，变色蜥、德州石龙子和波因塞特变色蜥分别出现明显至严重的嗜睡和厌食症状。感染后14天，所有3种蜥蜴均出现白细胞增多，血浆天冬氨酸转氨酶（AST）活性升高。在所有3种蜥蜴中均发现多灶性随机肝细胞坏死以及以成熟的莫卡西尼肝簇虫裂殖体为中心的肝内嗜异性粒细胞聚集。肺间质多处因以裂殖体为中心的嗜异性粒细胞聚集而增厚。在自然感染的蛇中未发现类似的临床或解剖病理变化。本研究结果表明，莫卡西尼肝簇虫能够在非自然的爬行动物宿主中引发坏死性炎症病变。
