Giuliano F, Rampin O, Bernabé J, Rousseau J P
Laboratoire de Physiologie de la Reproduction, Université Paris VI, France.
J Auton Nerv Syst. 1995 Oct 5;55(1-2):36-44. doi: 10.1016/0165-1838(95)00025-s.
The role of autonomic and somatic neural pathways involved in the control of penile erectile tissue was investigated in an in vivo rat model. Intracavernous pressure (ICP) changes were recorded during single or combined electrical stimulation of peripheral nerves in anesthetized rats. Stimulation of the pelvic and cavernous nerves elicited similar ICP increases. Ganglionic blockade abolished the response to pelvic nerve stimulation. Stimulation of the hypogastric nerve, the sensory or motor branches of the pudendal nerve, or the paravertebral sympathetic chain at L4-L5 by themselves did not produce any change in ICP. Stimulation of some of these nerves caused changes in ICP when combined with cavernous nerve stimulation. Stimulation of the paravertebral sympathetic chain reduced the ICP increases elicited by cavernous nerve stimulation. A decrease in ICP in response to cavernous nerve stimulation was also elicited by stimulation of the peripheral cut end of the sensory branch of the pudendal nerve or in paralyzed rats, the motor branch of the pudendal nerve. After sectioning the two branches of the pudendal nerve, stimulation of the sympathetic chain still reduced the ICP increase in response to cavernous nerve stimulation. Stimulation of the motor branch of the pudendal nerve during erection elicited by cavernous nerve stimulation was responsible for an additional ICP increase, which reached suprasystolic values. The present study confirms a proerectile role for parasympathetic pathways. Sympathetic fibers conveyed in both branches of the pudendal nerve exert an antierectile role in the rat. We identified an antierectile sympathetic outflow, originating in the caudal sympathetic chain, the anatomical arrangement of which remains unknown. In this model, penile erection appeared to be dependent on the recruitment of sacral parasympathetic outflow. Additional recruitment of efferent somatic fibers present in the motor branch of the pudendal nerve could participate in more rigid erection. This study provides new information about the organization of the pathways through which the rat penis is innervated, and would be of interest to investigators in the field of male sexual function.
在一个体内大鼠模型中，研究了自主神经和躯体神经通路在控制阴茎勃起组织方面的作用。在麻醉大鼠中，在对周围神经进行单次或联合电刺激期间记录海绵体内压（ICP）变化。刺激盆腔神经和海绵体神经引起相似的ICP升高。神经节阻断消除了对盆腔神经刺激的反应。单独刺激腹下神经、阴部神经的感觉或运动分支或L4-L5节段的椎旁交感神经链不会使ICP产生任何变化。当与海绵体神经刺激联合时，刺激其中一些神经会引起ICP变化。刺激椎旁交感神经链会降低海绵体神经刺激引起的ICP升高。刺激阴部神经感觉支的外周切断端或在瘫痪大鼠中刺激阴部神经运动支也会引起对海绵体神经刺激的ICP降低。切断阴部神经的两个分支后，刺激交感神经链仍会降低对海绵体神经刺激的ICP升高。在海绵体神经刺激引起的勃起过程中刺激阴部神经运动支会导致额外的ICP升高，达到收缩压以上的值。本研究证实了副交感神经通路的促勃起作用。阴部神经的两个分支中传导的交感纤维在大鼠中发挥抗勃起作用。我们确定了一种源自尾侧交感神经链的抗勃起交感神经传出，其解剖结构尚不清楚。在这个模型中，阴茎勃起似乎依赖于骶副交感神经传出的募集。阴部神经运动支中存在的传出躯体纤维的额外募集可能参与更坚挺的勃起。这项研究提供了关于大鼠阴茎神经支配通路组织的新信息，对男性性功能领域的研究人员具有重要意义。
