Loudon K W, Coke A P, Burnie J P, Shaw A J, Oppenheim B A, Morris C Q
Department of Medical Microbiology, Manchester Healthcare Trust, UK.
J Hosp Infect. 1996 Mar;32(3):191-8. doi: 10.1016/s0195-6701(96)90145-0.
In this study we investigated the epidemiology of a cluster of cutaneous infections owing to Aspergillus niger, which occurred in neutropenic patients in a bone marrow transplant unit. Heavy environmental contamination with the mould was found in the ward kitchen adjacent to the unit. The clinical and environmental isolates were typed by random amplification of polymorphic DNA (RAPD), which showed one of the patients was infected with the same strain as that isolated repeatedly from the kitchen area. In another case, contaminated stockinette material was implicated as the source of infection. Thorough cleaning of the ward kitchen resulted in no further cases on the unit. This highlights the fact that aspergilli may spread to patients by air, food or other vehicles, and underlines the importance of searching for a source and ensuring high levels of hospital hygiene are maintained.
在本研究中,我们调查了一起发生在骨髓移植病房中性粒细胞减少患者中的由黑曲霉引起的皮肤感染群的流行病学情况。在该病房相邻的厨房中发现了该霉菌的严重环境污染。通过随机扩增多态性DNA(RAPD)对临床和环境分离株进行分型,结果显示其中一名患者感染的菌株与多次从厨房区域分离出的菌株相同。在另一个病例中,受污染的针织品材料被认为是感染源。对病房厨房进行彻底清洁后,该病房未再出现新病例。这突出了曲霉可能通过空气、食物或其他媒介传播给患者这一事实,并强调了寻找感染源以及确保维持高水平医院卫生的重要性。