Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
Department of Oral and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany.
Eur Arch Otorhinolaryngol. 2023 Jun;280(6):2937-2944. doi: 10.1007/s00405-023-07884-3. Epub 2023 Mar 1.
Adenoid cystic carcinoma (ACC) is a rare type of cancer commonly occurring in salivary glands. It is characterized by slow but infiltrative growth, nerve infiltration and overall poor prognosis, with late recurrence and distant metastasis. The treatment of ACC is still limited to surgery and/or (adjuvant) radiotherapy. Till now no promising systemic therapy option exists. However, various studies deliver promising results after treatment with anti-angiogenetic agents, such as anti-EGFR-antibody Cetuximab or Tyrosinkinase inhibitor Lenvatinib.
By using of immunohistological methods we analyzed and compared the macrophage and lymphocyte populations, vascularization, and PD-L1-status in 12 ACC of the salivary glands.
All cases showed a significant elevation of macrophages with M2 polarization and a higher vascularization in ACC compared to normal salivary gland tissue. The CD4/CD8 quotient was heterogenous. ACC does not show relevant PD-L1 expression.
The predominant M2 polarization of macrophages in ACC could be responsible for elevated vascularization, as already been proved in other cancer types, that M2 macrophages promote angiogenesis.
腺样囊性癌（ACC）是一种罕见的癌症，常见于唾液腺。其特征是生长缓慢但具有浸润性，神经浸润和整体预后不良，晚期复发和远处转移。ACC 的治疗仍然限于手术和/或（辅助）放疗。到目前为止，还没有有效的系统治疗方法。然而，各种研究在使用抗血管生成药物治疗后显示出有希望的结果，例如抗 EGFR 抗体西妥昔单抗或酪氨酸激酶抑制剂仑伐替尼。
通过免疫组织化学方法，我们分析并比较了 12 例唾液腺腺样囊性癌中的巨噬细胞和淋巴细胞群体、血管生成和 PD-L1 状态。
与正常唾液腺组织相比，所有病例均显示 M2 极化的巨噬细胞显著升高和血管生成增加。CD4/CD8 比值不均一。ACC 不表达相关的 PD-L1。
ACC 中巨噬细胞的主要 M2 极化可能是血管生成升高的原因，正如已经在其他癌症类型中证明的那样，M2 巨噬细胞促进血管生成。
