Shimpo K, Chihara T, Hibiya M, Ito S, Nagatsu T
Institute for Comprehensive Medical Science, School of Medicine, Fujita Health University.
Nihon Rinsho. 1996 Jun;54(6):1515-20.
Polyamines (putrescine, spermidine and spermine) play important roles in cell proliferation and differentiation, and have been established as tumors markers. We and other workers have confirmed that N1-acetylspermidine in tumor tissues, spermidine and spermine in erythrocytes, and N1,N12-diacetylspermine in urine might be the most sensitive indicators for various forms of tumors. Neopterin is a marker of cell-mediated immunostimulation, and may be a helpful marker in monitoring cancer patients. HPLC and immunological assays of neopterin, biopterin, and N2-(3-aminopropyl)biopterin(oncopterin) in urine might be useful in the clinical study of pteridines, as cancer markers. Serum 5-S-cysteinyldopa level is a useful and specific biochemical marker for malignant melanoma.
多胺（腐胺、亚精胺和精胺）在细胞增殖和分化中发挥重要作用，并且已被确立为肿瘤标志物。我们及其他研究人员已证实，肿瘤组织中的N1-乙酰亚精胺、红细胞中的亚精胺和精胺以及尿液中的N1,N12-二乙酰精胺可能是各种肿瘤最敏感的指标。新蝶呤是细胞介导免疫刺激的标志物，可能是监测癌症患者的有用标志物。尿液中新蝶呤、生物蝶呤和N2-(3-氨丙基)生物蝶呤（癌蝶呤）的高效液相色谱法和免疫测定法可能在蝶啶的临床研究中作为癌症标志物有用。血清5-S-半胱氨酰多巴水平是恶性黑色素瘤有用且特异的生化标志物。
