Tomandl J
Biochemický ústav LF MU, Brno.
Vnitr Lek. 1997 Jun;43(6):404-6.
In the submitted review the author presents hitherto published data on the new tumour marker oncopterin which was assessed in urine of patients with different types of tumours. Oncopterin is a derivative of endogenous pterins and trimethylene amine needed for the synthesis of polyamines which are synthetized specially in proliferating cells. Urinary oncopterin excretion can be assessed by high resolution liquid chromatography (HPLC). As test for the presence of malignant growth it seems to have a relatively high specificity.
在提交的综述中，作者介绍了迄今为止已发表的关于新型肿瘤标志物蝶喋呤的数据，该标志物在不同类型肿瘤患者的尿液中进行了评估。蝶喋呤是内源性蝶呤和三甲胺的衍生物，而三甲胺是合成多胺所必需的，多胺特别在增殖细胞中合成。尿蝶喋呤排泄可通过高效液相色谱法（HPLC）进行评估。作为恶性肿瘤存在的检测方法，它似乎具有相对较高的特异性。
