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来自玻利维亚卡拉瓦亚草药医生的药物先导物。1. 背景、原理、方案及抗HIV活性。

Drug leads from the Kallawaya herbalists of Bolivia. 1. Background, rationale, protocol and anti-HIV activity.

作者信息

Abdel-Malek S, Bastien J W, Mahler W F, Jia Q, Reinecke M G, Robinson W E, Shu Y, Zalles-Asin J

机构信息

Department of Chemistry, Texas Christian University (TCU), Fort Worth 76129, USA.

出版信息

J Ethnopharmacol. 1996 Mar;50(3):157-66. doi: 10.1016/0378-8741(96)01380-3.

DOI:10.1016/0378-8741(96)01380-3
PMID:8691850
Abstract

Aqueous, organic and alcoholic extracts of over 100 samples of 60 species of Kallawaya medicinal herbs representing 30 plant families were assayed to compare their toxicity and ability to protect MT-2 T-lymphoblastoid cells from the cytopathic effect of human immunodeficiency virus (HIV). The results are reported as a therapeutic index (TI) which was > 25 for eighteen species, including seven > 50 and one > 100. The anti-HIV activity resided primarily in the aqueous rather than in the organic extracts and was concentrated in plants used in ethnomedicine to treat lung and liver diseases.

摘要

对代表30个植物科的60种卡拉瓦亚药用植物的100多个样本的水提取物、有机提取物和酒精提取物进行了分析,以比较它们的毒性以及保护MT-2 T淋巴母细胞免受人类免疫缺陷病毒(HIV)细胞病变效应影响的能力。结果以治疗指数(TI)表示,18种植物的治疗指数>25,其中7种>50,1种>100。抗HIV活性主要存在于水提取物而非有机提取物中,并且集中在用于民族医学治疗肺部和肝脏疾病的植物中。

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