Tedeschi B, Caporossi D, Vernole P, Padovani L, Mauro F
Department of Public Health and Cell Biology, University of Rome Tor Vergata, Italy.
Mutat Res. 1996 Jul 5;354(1):77-80. doi: 10.1016/0027-5107(96)00039-5.
In the present paper, we report data on the possible adaptive response, induced in vivo by exposure to ionizing radiation to a challenge treatment with the radiomimetic glycopeptide bleomycin (BLM). Lymphocytes from children living in Pripjat at the time of the Chernobyl accident, and thus hit by the initial acute dose of ionizing radiation, were treated for the last 5 h of culture with 0.004 U/ml BLM. Significantly lower chromosome damage was found only in lymphocytes from children who, independently of the initial acute exposure to ionizing radiation, still showed a 137Cs internal contamination, due to persistent continuous exposure to low doses of radiation. The present results indicate that past exposure to acute high dose of ionizing radiation does not interfere with resistance to BLM which is related to internal contamination.
在本论文中，我们报告了关于体内暴露于电离辐射后，对放射模拟糖肽博来霉素（BLM）激发处理产生的可能适应性反应的数据。切尔诺贝利事故发生时居住在普里皮亚季的儿童，其淋巴细胞受到了初始急性剂量的电离辐射，在培养的最后5小时用0.004 U/ml的BLM进行处理。仅在那些尽管最初急性暴露于电离辐射，但由于持续不断暴露于低剂量辐射仍显示有铯-137体内污染的儿童的淋巴细胞中，发现染色体损伤明显更低。目前的结果表明，过去暴露于急性高剂量电离辐射并不干扰与体内污染相关的对BLM的抗性。
