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The effect of some 2-substituted quinolines isolated from Galipea longiflora on Plasmodium vinckei petteri infected mice.

作者信息

Gantier J C, Fournet A, Munos M H, Hocquemiller R

机构信息

Laboratoire de Biologie et Contrôle des Organismes Parasites, Faculté de Pharmacie, Université Paris-Sud, Châtenay-Malabry, France.

出版信息

Planta Med. 1996 Jun;62(3):285-6. doi: 10.1055/s-2006-957883.

DOI:10.1055/s-2006-957883
PMID:8693048
Abstract

We have evaluated the in vivo antiplasmodial activity of six 2-substituted quinolines and a total alkaloidal extract of Galipea longiflora. BALB/c mice infected with Plasmodium vinckei petteri were treated orally at single dose of 50 mg/kg with quinolines or extract. Contrary to the previous results obtained with the Leishmania murine infection, 2-n-pentylquinoline showed activity against P. vinckei petteri. This result seems to confirm the antimalarial efficacy of infused stem bark of G. longiflora.

摘要

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