Cacciatore R, Helbling A, Jost C, Hess B
Medizinische Universitätspoliklinik, Inselspital Bern.
Praxis (Bern 1994). 1996 May 28;85(22):727-9.
By the example of two case reports, typical signs of caffeine withdrawal like headache, increased irritability, decreased performance and disturbed concentration are described. These symptoms occurred two times within one week in two healthy nonsmoking individuals volunteering in a scientific study including periods of 24 hours with standardized caffeine-free-diet. The two volunteers were used to a regular coffee consumption of eight cups per day (about 600 mg/day). Since caffeine obviously represents the most common psycho-stimulant worldwide and since even moderate coffee consumption may lead to dependence, withdrawal symptoms induced by sudden reduction of consumption or withdrawal of caffeine may occur more often than usually assumed.
通过两个病例报告的例子，描述了咖啡因戒断的典型症状，如头痛、易怒增加、表现下降和注意力不集中。在一项科学研究中，两名健康的非吸烟志愿者在一周内两次出现这些症状，该研究包括24小时的标准化无咖啡因饮食期。这两名志愿者习惯每天饮用八杯咖啡（约600毫克/天）。由于咖啡因显然是全球最常见的精神兴奋剂，而且即使适度饮用咖啡也可能导致依赖，因此因突然减少咖啡因摄入量或停用咖啡因而引起的戒断症状可能比通常认为的更频繁地发生。
