Williams D L, Hoey A J, Smitherman P
Beaumont Animals' Hospital, Royal Veterinary College, London.
Vet Rec. 1995 Dec 16;137(25):635-9.
Thirty dogs with chronic superficial keratitis (CSK) were randomly assigned to treatment with 0.2 per cent cyclosporin ointment or 0.1 per cent dexamethasone drops. They were treated for six weeks and examined before and after three and six weeks of treatment, and then every three weeks without treatment until the lesions recurred. The regression of the disease during the treatment and the time to a recurrence after the cessation of treatment were determined. Changes in the size of the corneal lesions were measured by image analysis of photographs taken at each examination, and the severity of adnexal changes such as conjunctival hyperaemia was assessed by means of a scoring system. Clinical evaluations suggested that both drugs were equally effective as treatments for CSK and a statistical analysis showed that they had reduced the size of the lesions to the same extent at each examination. There was a significant increase in tear production, measured by the Schirmer tear test, during the treatment with cyclosporin.
30只患有慢性浅层角膜炎（CSK）的犬被随机分配接受0.2%环孢素眼膏或0.1%地塞米松滴眼液治疗。它们接受治疗六周，在治疗三周和六周前后进行检查，然后在不治疗的情况下每三周检查一次，直至病变复发。确定治疗期间疾病的消退情况以及治疗停止后复发的时间。通过对每次检查时拍摄的照片进行图像分析来测量角膜病变大小的变化，并通过评分系统评估诸如结膜充血等附件变化的严重程度。临床评估表明，两种药物作为CSK的治疗方法同样有效，统计分析显示，在每次检查时它们将病变大小缩小到相同程度。在用环孢素治疗期间，通过Schirmer泪液试验测量的泪液分泌有显著增加。
