Dupré A, Christol B, Sorbara A M, Ghrenassia S
Ann Dermatol Venereol. 1977 Mar;104(3):195-9.
The authors have collected 6 cases (one personal case and 5 cases from the literature) of hyperkeratosis punctata of the palmar creases, an affection which seems to be a new type of keratosis punctata. It is characterized by the development of small horny plugs in small cup-like depressions which are electively and exclusively found in the palmar flexion creases of the fingers. Histological examination shows a plug-like hyperkeratosis penetrating, more or less deeply, the depressed, funnel-like Malpighi's mucous layer which sometimes consists of one layer of cells. This affection might be compared to Kyrle's disease (and the hyperkeratotic plugs of mechanical origin). The histological evidence of non-rupture of the dermis by the horny plugs may not be considered as a sufficient factor of differentiation: however, other clinical criteria differentiate these various affections. In the absence of a known etiology we must conclude that this type of keratosis punctata confined to the palmar creases is an autonomous disease.
作者收集了6例掌纹点状角化病（1例为个人病例，5例来自文献），这种病症似乎是一种新型的点状角化病。其特征是在小杯状凹陷处出现小角质栓，这些凹陷选择性且仅见于手指掌侧屈曲纹处。组织学检查显示，栓状角化过度或多或少地深入凹陷的漏斗状马尔皮基层，该层有时由一层细胞组成。这种病症可与凯尔氏病（以及机械性角质栓）相比较。角质栓未导致真皮破裂这一组织学证据可能不足以作为鉴别因素：然而，其他临床标准可区分这些不同病症。由于病因不明，我们必须得出结论，这种局限于掌纹处的点状角化病是一种独立的疾病。
