Mizuno M, Fujisawa R, Kuboki Y
Department of Biochemistry, School of Dentistry Hokkaido University, Sapporo Japan 060.
Calcif Tissue Int. 1996 Sep;59(3):163-7. doi: 10.1007/s002239900103.
Chondroadherin, which is reported to be synthesized by chondrocytes and to promote their attachment, was purified from bovine bone. It was a minor component of bone organic matrix, and was present in the 4 M guanidine extract of demineralized bone. Chondroadherin promoted attachment of osteoblastic cells to solid-state substrates, and bound to collagen. Binding of chondroadherin to collagen was significantly higher than that of osteonectin or decorin. These findings imply that chondroadherin may play a role in maintaining bone cells on the collagen matrices of bone.
软骨粘连蛋白据报道由软骨细胞合成并促进其附着，它是从牛骨中纯化得到的。它是骨有机基质的次要成分，存在于脱矿骨的4M胍提取物中。软骨粘连蛋白促进成骨细胞与固态底物的附着，并与胶原蛋白结合。软骨粘连蛋白与胶原蛋白的结合明显高于骨连接素或核心蛋白聚糖。这些发现表明软骨粘连蛋白可能在维持骨细胞于骨的胶原基质上发挥作用。
