Chang C C, Liao S T, Huang W S, Liu J D, Shih L S
Department of Internal Medicine, Taipei Municipal Jen-Ai Hospital, Taiwan.
J Formos Med Assoc. 1995 Sep;94(9):572-5.
Penicillium marneffei is a rare human pathogen in Southeast Asia and Southern China. A 26-year-old heterosexual male had intermittent fever, diarrhea and weight loss for 3 months. He was severely immune deficient (CD4+ count, 4/microL) and serologic tests for antibodies against human immunodeficiency virus type-1 were positive. P. marneffei infection was disseminated with involvement of the liver, spleen and bone marrow. The diagnosis was established by histologic examination and confirmed by isolation of the fungus. This infection responded well to amphotericin B. He was discharged with maintenance therapy of itraconazole and continued to be stable during his 2-month follow-up.
马尔尼菲青霉是东南亚和中国南方一种罕见的人类病原体。一名26岁的异性恋男性间歇性发热、腹泻和体重减轻3个月。他严重免疫缺陷（CD4 + 计数为4/微升），抗人类免疫缺陷病毒1型抗体的血清学检测呈阳性。马尔尼菲青霉感染播散至肝脏、脾脏和骨髓。通过组织学检查确诊，并经真菌分离证实。这种感染对两性霉素B反应良好。他出院时接受伊曲康唑维持治疗，在2个月的随访期间病情持续稳定。
