The Rel family of eukaryotic transcription factors.

Members of the Rel transcription factor family mediate the response of eukaryotic cells to a broad range of environmental threats, in addition to serving an essential role in the development of certain vertebrate and insect cells. It is now apparent that there are two classes of Rel proteins, which differ in whether they bind DNA as monomers or dimers and which use markedly different mechanisms to transduce intracellular signals. Recent progress has been made towards understanding the structural basis for the fascinating biology of these proteins.