Stables R H, Sigwart U
Department of Invasive Cardiology, Royal Brompton Hospital, London.
Heart. 1996 Jun;75(6):588-90. doi: 10.1136/hrt.75.6.588.
The benefits of intracoronary stent implantation are offset by an increased risk of complications at the arterial puncture site and a prolonged hospital stay. Much of this morbidity can be attributed to the generally perceived need to achieve systemic anticoagulation after stent implantation.
To test a simplified protocol for post-stent management using the Femostop pneumatic groin compression device and low molecular weight (fractionated) heparin (LMWH) administered by subcutaneous injection.
A case series of 100 consecutive patients, with stable angina pectoris, undergoing coronary stenting for a suboptimal result after conventional balloon angioplasty.
All patients were managed with a new post-stent protocol using the Femostop pneumatic groin compression device and LMWH. The incidence of complications and the length of hospital stay were recorded.
The clinical course was uncomplicated in 92 patients and their discharge from hospital was achieved on the first post-procedural day for 44 patients and on the second for the remaining 48. The rate of vascular or bleeding complications was 6%.
LMWH administered by subcutaneous injection may provide a practical and effective alternative to the use of intravenous heparin when systemic anticoagulation is used after stent implantation.
冠状动脉内支架植入的益处被动脉穿刺部位并发症风险增加和住院时间延长所抵消。这种发病率的增加很大程度上可归因于支架植入后普遍认为需要进行全身抗凝。
使用Femostop气动腹股沟压迫装置和皮下注射低分子量(分馏)肝素(LMWH)来测试一种简化的支架置入后管理方案。
一个包含100例连续患者的病例系列,这些患者患有稳定型心绞痛,在常规球囊血管成形术后冠状动脉支架置入效果欠佳。
所有患者均采用使用Femostop气动腹股沟压迫装置和LMWH的新的支架置入后方案进行管理。记录并发症发生率和住院时间。
92例患者临床过程无并发症,44例患者在术后第一天出院,其余48例在第二天出院。血管或出血并发症发生率为6%。
当支架植入后使用全身抗凝时,皮下注射LMWH可能是使用静脉肝素的一种实用且有效的替代方法。