急性剂量乙醇对大鼠大脑皮层和纹状体多巴胺能及5-羟色胺能系统的影响。

Effects of an acute dose of ethanol on dopaminergic and serotonergic systems from rat cerebral cortex and striatum.

作者信息

Gil-Martín E, Colado I, Fernández-López A, Fernández-Briera A, Calvo P

机构信息

Department of Biochemistry and Molecular Biology, University of León, Spain.

出版信息

Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1996 Mar;113(3):399-402. doi: 10.1016/0742-8413(96)00002-3.

DOI:10.1016/0742-8413(96)00002-3

PMID:8697197

Abstract

Intraperitoneal injection 10 min before sacrifice of 1.5 g ethanol/kg weight produced an increase in rat striatal levels of homovanillic acid (HVA) (p < 0.05) but did not affect the striatal concentrations of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA). A similar ethanol treatment led to decreases in 5-HT (p < 0.05) and 5-HIAA (p < 0.05) from cerebral cortex (prefrontal and anterior cingulate areas). The results point to several ethanol-linked alterations in central serotonergic and dopaminergic systems.

摘要

在处死大鼠前10分钟腹腔注射1.5克乙醇/千克体重，可使大鼠纹状体中高香草酸（HVA）水平升高（p < 0.05），但不影响纹状体中多巴胺（DA）、3,4 - 二羟基苯乙酸（DOPAC）、血清素（5 - HT）和5 - 羟基吲哚乙酸（5 - HIAA）的浓度。类似的乙醇处理导致大脑皮层（前额叶和前扣带区域）中5 - HT（p < 0.05）和5 - HIAA（p < 0.05）水平降低。结果表明中枢5 - 羟色胺能和多巴胺能系统存在几种与乙醇相关的变化。