大鼠前脑多巴胺能和5-羟色胺能指标的年龄相关变化。

Age-related changes in dopaminergic and serotonergic indices in the rat forebrain.

作者信息

Godefroy F, Bassant M H, Weil-Fugazza J, Lamour Y

机构信息

INSERM U 161, Paris, France.

出版信息

Neurobiol Aging. 1989 Mar-Apr;10(2):187-90. doi: 10.1016/0197-4580(89)90029-8.

DOI:10.1016/0197-4580(89)90029-8

PMID:2471092

Abstract

Age-related changes in the content of dopamine (DA), homovanillic acid (HVA), dihydroxyphenylacetic acid (DOPAC), 3-methoxytyramine (3-MT), serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in anterior cerebral cortex, hippocampus and striatum of the rat have been investigated using HPLC with electrochemical detection. A significant decrease in HVA was observed in the striatum and hippocampus of the aged (27 months) animals, as compared to the controls (2.4 to 2.6 months). A significant decrease in DA levels was also observed in the hippocampus but not in the striatum. In contrast, the level of DA in the cerebral cortex was markedly increased in the aged animals. A concomitant increase in 3-MT level was observed. Finally the level of 5-HIAA was significantly increased in striatum and hippocampus.

摘要

采用高效液相色谱-电化学检测法，研究了大鼠大脑前皮质、海马体和纹状体中多巴胺（DA）、高香草酸（HVA）、二羟基苯乙酸（DOPAC）、3-甲氧基酪胺（3-MT）、5-羟色胺（5-HT）和5-羟基吲哚乙酸（5-HIAA）含量随年龄的变化。与对照组（2.4至2.6个月）相比，老龄（27个月）动物的纹状体和海马体中HVA显著降低。海马体中DA水平也显著降低，但纹状体中未降低。相反，老龄动物大脑皮质中DA水平显著升高，同时3-MT水平升高。最后，纹状体和海马体中5-HIAA水平显著升高。