Thomé-Duret V, Gangnerau M N, Zhang Y, Wilson G S, Reach G
INSERM U341, Service de Diabétologie, Hôtel-Dieu, Paris, France.
Diabetes Metab. 1996 Jun;22(3):174-8.
The mechanism of reducing the glucose sensitivity of sensors implanted into the subcutaneous tissue of the normal rat was evaluated (n = 10) by comparing sensitivities observed in vitro and in vivo. In vivo sensitivity was significantly lower than that observed in vitro before implantation (p < 0.005). Most interestingly, in vitro sensitivity immediately after explanation did not differ from that in vivo and increased progressively during rinsing (p < 0.02 after 30 min). These results demonstrate that the reduction of in vivo sensitivity was not due to a local factor or factors but to a reversible alteration of the glucose sensor characteristics induced in vivo by some local factor(s). This suggests that modifications of the outer sensor membrane, the nature of which remains to be determined, may prevent this effect and resolve the problem.
通过比较正常大鼠皮下组织植入传感器在体外和体内的灵敏度，评估了降低其葡萄糖敏感性的机制（n = 10）。体内灵敏度显著低于植入前体外观察到的灵敏度（p < 0.005）。最有趣的是，取出后立即测量的体外灵敏度与体内灵敏度无差异，且在冲洗过程中逐渐增加（30分钟后p < 0.02）。这些结果表明，体内灵敏度的降低不是由于局部因素，而是由于某些局部因素在体内诱导的葡萄糖传感器特性的可逆改变。这表明，外部传感器膜的修饰（其性质尚待确定）可能会防止这种效应并解决该问题。
