急性恶性疟原虫疟疾患者血清中可溶性CD14水平升高。
Elevated levels of soluble CD14 in serum of patients with acute Plasmodium falciparum malaria.
作者信息
Wenisch C, Wenisch H, Parschalk B, Vanijanonta S, Burgmann H, Exner M, Zedwitz-Liebenstein K, Thalhammer F, Georgopoulos A, Graninger W, Looareesuwan S
机构信息
Department of Infectious Diseases, Internal Medicine I, University Hospital of Vienna, Austria.
出版信息
Clin Exp Immunol. 1996 Jul;105(1):74-8. doi: 10.1046/j.1365-2249.1996.d01-723.x.
Serum sCD14, tumour necrosis factor-alpha (TNF-alpha), IL-6, and endotoxin were analysed in 45 patients with complicated malaria, in 14 patients with Gram-negative septicaemia and in 24 healthy subjects by ELISA. Malaria patients with renal failure (n = 16) had higher levels than patients without renal failure (n = 29) (8116 + 1440 micrograms/l versus 9453 + 1017 micrograms/l; P < 0.05) and both had higher levels than patients with septicaemia (6155 + 1635 micrograms/l) and normal subjects (2776 + 747 micrograms/l). A significant correlation between sCD14 and IL-6 (r = 0.756) and TNF (r = 0.822) existed. However, no relation between sCD14 and serum endotoxin or indices of clinical disease severity (parasitaemia, fever, parasite or fever clearance time) was seen. Although the role of sCD14 in malaria remains to be determined, elevated levels may participate in the inflammatory response in complicated malaria.
通过酶联免疫吸附测定法（ELISA）对45例复杂型疟疾患者、14例革兰氏阴性败血症患者和24名健康受试者的血清可溶性CD14（sCD14）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和内毒素进行了分析。肾衰竭的疟疾患者（n = 16）的水平高于无肾衰竭的患者（n = 29）（8116±1440微克/升对9453±1017微克/升；P<0.05），且二者的水平均高于败血症患者（6155±1635微克/升）和正常受试者（2776±747微克/升）。sCD14与IL-6（r = 0.756）和TNF（r = 0.822）之间存在显著相关性。然而，未观察到sCD14与血清内毒素或临床疾病严重程度指标（寄生虫血症、发热、寄生虫或发热清除时间）之间存在关联。尽管sCD14在疟疾中的作用尚待确定，但水平升高可能参与了复杂型疟疾的炎症反应。
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