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[安徽省农村地区0-3岁儿童脊髓灰质炎病毒中和抗体水平监测]

[Surveillance of levels of neutralizing antibodies against poliovirus among children aged 0-3 in rural areas of Anhui Province].

作者信息

Shen Y, Zhao Y, Liu D

机构信息

Anhui Provincial Anti-epidemic Station, Hefei.

出版信息

Zhonghua Yu Fang Yi Xue Za Zhi. 1995 Nov;29(6):335-8.

PMID:8697935
Abstract

Levels of neutralizing antibodies against poliovirus (PV) in 1,755 children aged 0-3 sampled randomly from 18 counties in Anhui Province were determined in September, 1993. Results showed the positive rates and geometric mean titer (GMT) of neutralizing antibodies against PV type 1, 2 and 3 were 96.98%, 96.01% and 96.18%, and 524.80, 323.59 and 436.50, respectively. Immune level of children was considerable high in each county sampled. No significant difference was found among different age groups and between boys and girls in positive rates and GMT of polioantibodies, but there was significant difference in them between children administered varied doses of oral polio vaccine (OPV). Children investigated took four doses of OPV in average, and their GMT was in proportion to the dose they took. Positive rate of PV antibodies was more than 95% in children who finished the full course of OPV immunization. There were very few townships or villages with a low coverage of OPV immunization in children. It indicated polio immune status was in a higher level in the Province.

摘要

1993年9月,对从安徽省18个县随机抽取的1755名0至3岁儿童的脊髓灰质炎病毒(PV)中和抗体水平进行了测定。结果显示,1型、2型和3型PV中和抗体的阳性率和几何平均滴度(GMT)分别为96.98%、96.01%和96.18%,以及524.80、323.59和436.50。在所抽样的每个县,儿童的免疫水平相当高。脊髓灰质炎抗体的阳性率和GMT在不同年龄组以及男孩和女孩之间未发现显著差异,但在服用不同剂量口服脊髓灰质炎疫苗(OPV)的儿童之间存在显著差异。被调查儿童平均服用了四剂OPV,其GMT与服用剂量成正比。完成OPV全程免疫的儿童中PV抗体阳性率超过95%。儿童OPV免疫接种覆盖率低的乡镇或村庄极少。这表明该省脊髓灰质炎免疫状况处于较高水平。

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