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[脊髓灰质炎疫苗免疫研究。II. 不同剂型脊髓灰质炎疫苗接种反应的比较]

[A study on immunization of polio vaccine. II. Comparison of responses obtained by different forms of polio vaccine].

作者信息

Su W

机构信息

National Vaccine and Serum Institute Beijing.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 1991 Oct;12(5):284-5.

PMID:1664296
Abstract

A comparison study on the responses to the immunization of three different forms of polio vaccine, eg. Liquid I, Oral dragee candy I and Trivalent Oral dragee candy, on the susceptible children of 2-6 month of age was conducted in wujin County, Jiangsu Province The study showed no statistical difference between the responses to the three forms of the vaccine reaching 95-100%. For antibody GMT, Liquid I was the highest, with little difference between Liquid I and Oral dragee candy I and Trivalent Oral dragee candy vaccine in statistics. But, there was a significant statistical difference between Trivalent Oral dragee candy and Liquid I. Considering that it is not easy to inoculate the children of 2-4 months of age with oral dragee candy vaccine, it is suggested all the producers try their best to convert the present oral dragee candy form into Liquid.

摘要

在江苏省武进县对2至6月龄易感儿童进行了三种不同剂型脊髓灰质炎疫苗(即液体I型、口服糖丸I型和三价口服糖丸)免疫反应的比较研究。研究表明,三种剂型疫苗的免疫反应达到95%至100%,无统计学差异。抗体几何平均滴度(GMT)以液体I型最高,液体I型与口服糖丸I型及三价口服糖丸疫苗在统计学上差异不大,但三价口服糖丸与液体I型之间存在显著统计学差异。鉴于2至4月龄儿童口服糖丸疫苗接种不易,建议各生产厂家尽量将现有的口服糖丸剂型改为液体剂型。

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