Cunze T, Osmers R, Lefhalm B, Wieding J, Fadaian-Motlagh S, Kuhn W
Department of Gynecology and Obstetrics, University of Göttingen, Germany.
Gynecol Obstet Invest. 1996;41(3):183-8. doi: 10.1159/000292265.
Fibronectin can be detected in the plasma and the extracellular matrix of the uterus of pregnant women. Studies so far have compared individual observations, whilst serial investigations during pregnancy, and during and after parturition have not been carried out. Plasma fibronectin levels were measured in 153 women with healthy pregnancies in relation to the gestational age. During parturition, blood was taken from the inception of labor through to parturition, and on the 1st, 3rd, and 5th days after parturition. The investigations of the plasma fibronectin level in pregnant women show constant concentrations up to the 35th week of pregnancy. From the 36th week onward the fibronectin rises significantly before dropping to the initial values at the start of labor. The elevated fibronectin concentration in the last 4 weeks before delivery could be explained both by renewed, elevated synthesis in the uterus and placenta as well as by lower consumption. The decline in the fibronectin level with the onset of labor could be caused by an elevated enzymatic induction in the uteroplacental unit in connection with the start of parturition.
在孕妇血浆和子宫细胞外基质中可检测到纤连蛋白。迄今为止的研究都是比较个体观察结果，而尚未对孕期、分娩期间及分娩后进行连续调查。对153名妊娠健康的女性，根据孕周测定了血浆纤连蛋白水平。在分娩期间，从临产开始至分娩以及在分娩后的第1、3和5天采集血液。对孕妇血浆纤连蛋白水平的研究表明，在妊娠35周之前浓度保持恒定。从第36周起，纤连蛋白显著升高，然后在临产前降至初始值。分娩前最后4周纤连蛋白浓度升高，这既可以通过子宫和胎盘合成重新增加、升高来解释，也可以通过消耗降低来解释。随着分娩开始，纤连蛋白水平下降可能是由于与分娩开始相关的子宫胎盘单位中酶诱导增加所致。
