Holloway H, Mullen W, Fielding J F
Royal College of Surgeons, Dublin, Ireland.
Ir J Med Sci. 1996 Apr-Jun;165(2):95-8. doi: 10.1007/BF02943792.
Knowledge of the presence and the degree of inflammation in Crohn's disease would be useful in multicentre therapeutic trials. Objectives; The purpose of the present study was two fold, a) to determine the relationship between clinical assessment of activity by two clinicians with four previously published indices, the Crohn's disease activity index (CDAI), the Van Hees activity index (AI), the simple index of Harvey and Bradsaw (SI) and the Fielding index and b) for the first time, to study the internal correlation between these four indices.
A hundred and ninety-four assessments were performed on 56 patients with Crohn's disease. Following each clinical assessment, the aforementioned indices were calculated.
Both clinicians gave the same rating of activity in 81% (157) of assessments. A good relationship was observed between the median indical values and the clinical gradings for all four indices. The best relationship was demonstrated with the AI with no overlap in 50% values with increasing grades of disease activity. All four indices demonstrated a good correlation with each other (p < 0.01). The best correlation was observed between more objective indices the AI and the Fielding index (r = 0.79) for first assessments only. Conclusion. The Van Hees AI is a reliable measure of inflammatory activity in Crohn's disease and would be useful in multicentre therapeutic trials.
了解克罗恩病炎症的存在情况及程度对于多中心治疗试验很有用。目的：本研究的目的有两个，a）确定两名临床医生对活动度的临床评估与四个先前发表的指标之间的关系，这四个指标分别是克罗恩病活动指数（CDAI）、范赫斯活动指数（AI）、哈维与布拉德肖简易指数（SI）和菲尔丁指数；b）首次研究这四个指标之间的内部相关性。
对56例克罗恩病患者进行了194次评估。每次临床评估后，计算上述指标。
两位临床医生在81%（157次）的评估中给出了相同的活动度评分。所有四个指标的中位数指标值与临床分级之间均观察到良好的关系。与AI的关系最佳，随着疾病活动度等级增加，50%的值无重叠。所有四个指标之间均显示出良好的相关性（p < 0.01）。仅在首次评估时，在更客观的指标AI和菲尔丁指数之间观察到最佳相关性（r = 0.79）。结论。范赫斯AI是克罗恩病炎症活动的可靠指标，对多中心治疗试验有用。
