Kao J H, Chen P J, Hsiang S C, Chen W, Chen D S
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Republic of China.
J Infect Dis. 1996 Aug;174(2):410-3. doi: 10.1093/infdis/174.2.410.
A group of flavi-like GB viruses (GBV-A, -B, and -C) has been discovered and partially characterized. Only GBV-C is found in humans. Nucleotide sequences of the putative helicase gene of the GBV-C genome were determined in 21 Taiwanese patients and compared with isolates from Africa and North America by phylogenetic analysis. The average similarities of Taiwanese isolates to those from West Africa, East Africa, Canada, and United States were 83%, 85%, 78%, and 82%, respectively. Phylogenetic analysis of the NS3 region showed that 81% of the Taiwanese isolates were more closely related to the East African isolate. GBV-C isolates from Taiwan could be classified into at least 3 groups. These data suggest that GBV-C isolates cloned from different geographic areas have genetic heterogeneity.
一组类黄病毒属GB病毒（GBV - A、- B和- C）已被发现并部分加以表征。仅GBV - C在人类中被发现。在21名台湾患者中测定了GBV - C基因组假定解旋酶基因的核苷酸序列，并通过系统发育分析与来自非洲和北美的分离株进行了比较。台湾分离株与来自西非、东非、加拿大和美国的分离株的平均相似性分别为83%、85%、78%和82%。NS3区域的系统发育分析表明，81%的台湾分离株与东非分离株关系更为密切。来自台湾的GBV - C分离株可至少分为3组。这些数据表明，从不同地理区域克隆的GBV - C分离株具有遗传异质性。
