Lange R D, Andrews R B, Gibson L A, Congdon C C, Wright P, Dunn C D, Jones J B
Am J Physiol. 1987 Feb;252(2 Pt 2):R216-21. doi: 10.1152/ajpregu.1987.252.2.R216.
Previous studies have shown that a decrease in red cell mass occurs in astronauts, and some studies indicate a leukocytosis occurs. A life science module housing young and mature rats was flown on shuttle mission Spacelab 3 (SL-3), and the results of hematology studies of flight and control rats are presented. Statistically significant increases in the hematocrit, red blood cell counts, and hemoglobin determinations, together with a mild neutrophilia and lymphopenia, were found in flight animals. No significant changes were found in bone marrow and spleen cell differentials or erythropoietin determinations. Clonal assays demonstrated an increased erythroid colony formation of flight animal bone marrow cells at erythropoietin doses of 0.02 and 1.0 U/ml but not 0.20 U/ml. These results agree with some but vary from other previously published studies. Erythropoietin assays and clonal studies were performed for the first time.
先前的研究表明，宇航员的红细胞量会减少，一些研究则表明会出现白细胞增多。一个搭载幼年和成年大鼠的生命科学舱在航天飞机任务“太空实验室3号”（SL - 3）中飞行，本文展示了飞行大鼠和对照大鼠的血液学研究结果。在飞行动物中发现，血细胞比容、红细胞计数和血红蛋白测定值有统计学意义的显著增加，同时伴有轻度中性粒细胞增多和淋巴细胞减少。骨髓和脾细胞分类或促红细胞生成素测定未发现显著变化。克隆试验表明，在促红细胞生成素剂量为0.02和1.0 U/ml而非0.20 U/ml时，飞行动物骨髓细胞的红系集落形成增加。这些结果与一些先前发表的研究一致，但与其他研究不同。促红细胞生成素测定和克隆研究首次进行。
