Prpić-Majić D, Pizent A, Jurasović J, Pongracić J, Restek-Samarzija N
Institute for Medical Research and Occupational Health, Zagreb, Croatia.
J Toxicol Clin Toxicol. 1996;34(4):417-23. doi: 10.3109/15563659609013812.
The aim of this study was to confirm the connection between lead poisoning and the use of traditional Ayurvedic metal mineral tonics.
The study group comprised 29 subjects (26 adults and three children) who had previously taken Ayurvedic metal mineral tonics. All subjects were tested for lead absorption by blood lead, erythrocyte delta-aminolevulinic acid dehydratase activity and erythrocyte protoporphyrin.
Eighteen samples of Ayurvedic preparations were obtained from 15 subjects and analyzed for lead content. Five adult subjects with established lead poisoning received chelation therapy. In Ayurvedic preparations a wide range of lead content was found (0.9-72,990 micrograms Pb/g; 0.35-29,900 micrograms Pb/capsule or tablet). The blood lead, erythrocyte delta-aminolevulinic acid dehydratase and erythrocyte protoporphyrin of the subjects, grouped according to the remedies used, correlated with the lead content in the preparations (p < 0.001). Chelation therapy was successful in normalization of laboratory findings and clinical recovery.
Ayurvedic metal-mineral tonics are again identified as a potential source of high lead. The import of such tonics should be strictly controlled.
本研究旨在证实铅中毒与传统阿育吠陀金属矿物滋补剂的使用之间的联系。
研究组包括29名曾服用阿育吠陀金属矿物滋补剂的受试者（26名成年人和3名儿童）。所有受试者均通过血铅、红细胞δ-氨基乙酰丙酸脱水酶活性和红细胞原卟啉检测铅吸收情况。
从15名受试者处获得了18份阿育吠陀制剂样本，并分析了铅含量。5名确诊铅中毒的成年受试者接受了螯合疗法。在阿育吠陀制剂中发现铅含量范围很广（0.9 - 72,990微克铅/克；0.35 - 29,900微克铅/胶囊或片剂）。根据所使用的药物分组的受试者的血铅、红细胞δ-氨基乙酰丙酸脱水酶和红细胞原卟啉与制剂中的铅含量相关（p < 0.001）。螯合疗法成功使实验室检查结果恢复正常并实现了临床康复。
阿育吠陀金属矿物滋补剂再次被确定为高铅的潜在来源。此类滋补剂的进口应受到严格控制。
