Migliozzi J A
Br J Cancer. 1977 Apr;35(4):448-53. doi: 10.1038/bjc.1977.67.
The growth of tumours in guinea-pigs was observed for 20 weeks after placing them on various doses of vitamin C. Complete tumour regression occurred in 55% of those animals receiving 0-3 mg/kg/day ascorbic acid, whereas animals given 10 mg/kg/day showed tumour inhibition but no regression. In contrast, tumours in animals maintained on 1 g/kg/day ascorbic acid grew without sign of retardation. When increased amounts of ascorbic acid were restored to the diet of scorbutic tumour-bearing animals, tumours which had not regressed responded with enhanced growth. Likewise, animals previously maintained on 10 mg/kg ascorbic acid responded in turn to the additional vitamin with enhanced tumour growth. In contrast, all tumour-bearing animals maintained on 1 g/kh ascorbic acid died within 3 weeks when this dose was replaced with 0-3 mg/kg.
给豚鼠投喂不同剂量的维生素C后，观察其肿瘤生长20周。在接受0 - 3毫克/千克/天抗坏血酸的动物中，55%出现了肿瘤完全消退，而给予10毫克/千克/天的动物显示出肿瘤受到抑制但未消退。相比之下，以1克/千克/天抗坏血酸饲养的动物的肿瘤生长未出现减缓迹象。当向患坏血病的荷瘤动物饮食中恢复增加量的抗坏血酸时，未消退的肿瘤生长加速。同样，先前以10毫克/千克抗坏血酸饲养的动物，额外补充维生素后肿瘤生长也增强。相反，所有以1克/千克抗坏血酸饲养的荷瘤动物，当该剂量替换为0 - 3毫克/千克时，在3周内死亡。
