英国成年人的伯基特淋巴瘤：临床特征及对化疗的反应
Burkitt's lymphoma in British adults: clinical features and response to chemotherapy.
作者信息
Brearley R L, Lister T A, Whitehouse J M, Stansfeld A G
出版信息
Br J Cancer. 1977 Apr;35(4):484-7. doi: 10.1038/bjc.1977.72.
Eight British adults with tumours histologically and cytochemically identical to African Burkitt's lymphoma are described. In each case there was an acute clinical onset and similar tumour distribution, with involvement of the intra-abdominal organs, bone marrow and central nervous system. Jaw tumours were only present in 3 cases, and were never gross. Four patients presented as acute leukaemia. Combination chemotherapy and cranial irradiation were used to eradicate disease, but complete remissions were obtained in only 3 patients, and survival of over 1 year in only 2. The remainder died with disease present, less than 5 months from diagnosis.
本文描述了8名英国成年人，他们的肿瘤在组织学和细胞化学上与非洲伯基特淋巴瘤相同。每例患者均有急性临床发病，肿瘤分布相似，累及腹腔内器官、骨髓和中枢神经系统。仅3例患者出现颌部肿瘤，且均未形成肉眼可见的肿块。4例患者表现为急性白血病。采用联合化疗和颅脑放疗来根除疾病，但仅3例患者获得完全缓解，仅2例患者存活超过1年。其余患者在疾病存在的情况下死亡，从诊断到死亡不到5个月。
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