Nozawa I, Imamura S, Fujimori I, Hashimoto K, Shimomura S, Hisamatsu K, Murakami Y
Department of Otolaryngology, Yamanashi Medical University, Japan.
Laryngoscope. 1996 Aug;106(8):1034-9. doi: 10.1097/00005537-199608000-00024.
The auditory brainstem response (ABR) and the eight nerve compound action potential (CAP) were measured using click click stimuli to investigate the age-related alteration in the auditory function in 66 guinea pigs consisting of four age groups. With advancing age, a gradual elevation of the thresholds in both the ABR and CAP was clearly seen, together with the prolonged latencies for waves I, II, III, and IV to clicks at 95 dBpeSPL in the ABR. There were some individual differences in either threshold elevation or latency prolongation of both the ABR and CAP in aged guinea pigs. These findings suggest that the effect of individual differences on degenerative aging processes of the auditory system should be considered in selected aged animals, although a significant elevation of the neural auditory threshold is clearly found with advancing age as a whole.
使用短声刺激测量了66只豚鼠（分为四个年龄组）的听性脑干反应（ABR）和第八对脑神经复合动作电位（CAP），以研究听觉功能随年龄的变化。随着年龄的增长，ABR和CAP的阈值均明显逐渐升高，同时ABR中95 dBpeSPL短声刺激下I、II、III和IV波的潜伏期延长。老年豚鼠的ABR和CAP在阈值升高或潜伏期延长方面存在个体差异。这些发现表明，在选择老年动物时应考虑个体差异对听觉系统退行性衰老过程的影响，尽管总体上随着年龄的增长神经听觉阈值明显升高。
