Jackson C W, Edwards C C
Br J Haematol. 1977 Feb;35(2):233-44. doi: 10.1111/j.1365-2141.1977.tb00580.x.
Thrombopoiesis has been studied during and after an 11 d exposure to discontinuous hypobaric hypoxia. Exposure of rats to 0.4 atmospheres for 16--17 h daily initially caused an increase in platelet count which reached a peak of 1.5 times baseline on days 4 and 5. This thrombocytosis was followed by a decrease in platelets to a nadir of 50--60% of baseline on days 12 and 13. That thrombocytosis results from increased platelet production is supported by increased [35S]sulphate incorporation into platelets and increased megakaryocyte size and turnover. The thrombocytopenia with continued hypoxia seems to result from decreased platelet production since 51Cr-platelet survival was normal while megakaryocyte concentration was decreased to one-half that of untreated controls. These observations suggest that differentiation of precursors into megakaryocytes was decreased during the thrombocytopenic period, although the fewer remaining megakaryocytes appeared stimulated because of their larger size and increased [3H]thymidine labelling. Thus, hypobaric hypoxia had a biphasic effect on thrombopoiesis with increased platelet production in the first few days of exposure followed by subnormal production.
在暴露于间断性低压缺氧11天期间及之后，对血小板生成进行了研究。大鼠每天暴露于0.4个大气压下16 - 17小时，最初会导致血小板计数增加，在第4天和第5天达到峰值，为基线的1.5倍。这种血小板增多症之后，血小板数量在第12天和第13天降至最低点，为基线的50 - 60%。血小板增多是由于血小板生成增加，这一点得到了支持，即[35S]硫酸盐掺入血小板增加，巨核细胞大小和更新增加。持续缺氧导致的血小板减少似乎是由于血小板生成减少，因为51Cr标记的血小板存活正常，而巨核细胞浓度降至未处理对照组的一半。这些观察结果表明，在血小板减少期，前体细胞向巨核细胞的分化减少，尽管剩余的较少巨核细胞由于其较大的尺寸和增加的[3H]胸腺嘧啶核苷标记而似乎受到刺激。因此，低压缺氧对血小板生成有双相作用，在暴露的最初几天血小板生成增加，随后生成低于正常水平。
