Kim J, Sebring A, Esch J J, Kraus M E, Vorwerk K, Magee J, Carroll S B
Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, 53706, USA.
Nature. 1996 Jul 11;382(6587):133-8. doi: 10.1038/382133a0.
Appendage formation is organized by signals from discrete sources that presumably act upon downstream genes to control growth and patterning. The Drosophila vestigial gene is selectively required for wing-cell proliferation, and is sufficient to induce outgrowths of wing tissue from eyes, legs and antennae. Different signals activate separate enhancers to control vestigial expression: first, in the dorsal/ventral organizer through the Notch pathway, and subsequently, in the developing wing blade by decapentaplegic and a signal from the dorsal/ventral organizer. Signal integration must be a general feature of genes like vestigial, that regulate growth or patterning along more than one axis.
附肢的形成是由来自离散源的信号所组织的，这些信号可能作用于下游基因以控制生长和模式形成。果蝇的残翅基因对于翅细胞增殖是选择性必需的，并且足以诱导眼、腿和触角处长出翅组织。不同的信号激活不同的增强子来控制残翅基因的表达：首先，通过Notch信号通路在背/腹组织者中激活，随后，在发育中的翅叶片中由截瘫基因和来自背/腹组织者的信号激活。信号整合必定是像残翅基因这类沿多个轴调节生长或模式形成的基因的一个普遍特征。
