Nedivi E, Fieldust S, Theill L E, Hevron D
Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel.
Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2048-53. doi: 10.1073/pnas.93.5.2048.
Activity-dependent plasticity is thought to underlie both formation of appropriate synaptic connections during development and reorganization of adult cortical topography. We have recently cloned many candidate plasticity-related genes (CPGs) induced by glutamate-receptor activation in the hippocampus. Screening the CPG pool for genes that may contribute to neocortical plasticity resulted in the identification of six genes that are induced in adult visual cortical areas in response to light. These genes are also naturally induced during postnatal cortical development. CPG induction by visual stimulation occurs primarily in neurons located in cortical layers II-III and VI and persists for at least 48 hr. Four of the visually responsive CPGs (cpg2, cpg15, cpg22, cpg29) are previously unreported genes, one of which (cpg2) predicts a "mini-dystrophin-like" structural protein. These results lend molecular genetic support to physiological and anatomical studies showing activity-dependent structural reorganization in adult cortex. In addition, these results provide candidate genes the function of which may underlie mechanisms of adult cortical reorganization.
活动依赖型可塑性被认为是发育过程中适当突触连接形成以及成年皮质拓扑结构重组的基础。我们最近克隆了许多由海马体中谷氨酸受体激活诱导的候选可塑性相关基因（CPG）。在CPG库中筛选可能有助于新皮质可塑性的基因，结果鉴定出六个在成年视觉皮质区域对光产生反应而被诱导的基因。这些基因在出生后皮质发育过程中也会自然诱导产生。视觉刺激诱导CPG主要发生在位于皮质层II - III和VI的神经元中，并持续至少48小时。四个视觉反应性CPG（cpg2、cpg15、cpg22、cpg29）是以前未报道的基因，其中一个（cpg2）预测为一种“微小肌营养不良蛋白样”结构蛋白。这些结果为生理和解剖学研究提供了分子遗传学支持，这些研究表明成年皮质中存在活动依赖型结构重组。此外，这些结果提供了候选基因，其功能可能是成年皮质重组机制的基础。
