Tokui N, Nishisaka S, Mizoue T, Utoguchi K, Yoshimura T
Department of Clinical Epidemiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
J UOEH. 1996 Jun 1;18(2):133-40. doi: 10.7888/juoeh.18.133.
The aim of this study is to clarify the relationship between the incidence of atrophic gastritis and Helicobacter pylori infection. A case control study was conducted in 1995. Cases and controls were selected among those who took an annual health examination in a rural area of Fukuoka Prefecture. Cases are those who were not diagnosed as having atrophic gastritis in 1991 or 1992 but were diagnosed as having atrophic gastritis in 1995 by the examination of serum pepsinogens. Controls are those who were not diagnosed as having atrophic gastritis between 1991, or 1992 and 1995. Helicobacter pylori infection was evaluated by anti Helicobacter pylori IgG in 1995. The odds ratio for atrophic gastritis was calculated using Logistic regression analysis. The odds ratio of age and sex was not significant, but the odds ratio of Helicobacter pylori infection was significantly elevated (5.2, 95% confidence interval: 2.08-13.17). As for the influence of sex difference on the incidence of atrophic gastritis by Helicobacter pylori infection, the odds ratio among males was not significant (1.4, 95% confidence interval: 0.30-6.10), but the odds ratio among females was significantly high (9.8, 95% confidence interval: 2.82-34.11). These results suggest that Helicobacter pylori infection is associated with the incidence of atrophic gastritis. There may be a risk difference between males and females in the incidence of atrophic gastritis caused by Helicobacter pylori infection.
本研究的目的是阐明萎缩性胃炎发病率与幽门螺杆菌感染之间的关系。1995年进行了一项病例对照研究。病例和对照选自福冈县农村地区参加年度健康检查的人群。病例是那些在1991年或1992年未被诊断为萎缩性胃炎，但在1995年通过血清胃蛋白酶原检查被诊断为萎缩性胃炎的人。对照是那些在1991年、1992年至1995年期间未被诊断为萎缩性胃炎的人。1995年通过抗幽门螺杆菌IgG评估幽门螺杆菌感染情况。使用逻辑回归分析计算萎缩性胃炎的比值比。年龄和性别的比值比不显著，但幽门螺杆菌感染的比值比显著升高（5.2，95%置信区间：2.08 - 13.17）。至于幽门螺杆菌感染对萎缩性胃炎发病率的性别差异影响，男性的比值比不显著（1.4，95%置信区间：0.30 - 6.10），但女性的比值比显著较高（9.8，95%置信区间：2.82 - 34.11）。这些结果表明，幽门螺杆菌感染与萎缩性胃炎的发病率有关。幽门螺杆菌感染导致的萎缩性胃炎发病率在男性和女性之间可能存在风险差异。
