Watanabe Y, Ozasa K, Higashi A, Hayashi K, Mizuno S, Mukai M, Inokuchi H, Miki K, Kawai K
Department of Preventive Medicine, Kyoto Prefectural University of Medicine, Japan.
J Clin Gastroenterol. 1997 Jul;25(1):391-4. doi: 10.1097/00004836-199707000-00024.
We enrolled five hundred twenty-one patients with atrophic gastritis and 769 controls in a case-control study of atrophic gastritis and Helicobacter pylori infection and lifestyle factors. The participants had no history of upper gastrointestinal surgery. They were selected from 1,395 adult (35 years or older) residents of a rural town in Kyoto prefecture who participated in an annual health examination in 1987. Atrophic gastritis was diagnosed on the basis of serum pepsinogen levels: pepsinogen I levels (< or = 70 ng/ml) and pepsinogen I/pepsinogen II ratios (< or = 3.0). The presence of immunoglobulin G antibodies to H. pylori indicated H. pylori infection. At the time of the health examination, participants were interviewed about daily lifestyle habits such as use of cigarettes and alcoholic beverages and consumption of green-yellow vegetables. Unconditional logistic regression analysis indicated that H. pylori infection was associated with a significantly increased risk for atrophic gastritis for all participants (odds ratio, 8.17; 95% confidence interval, 5.63-11.84); for men (odds ratio, 10.91; 95% CI, 5.25-22.67); and for women (odds ratio, 7.28; 95% CI, 4.72-11.22). We found no statistically significant relations between lifestyle factors and atrophic gastritis.
我们纳入了521例萎缩性胃炎患者和769名对照者，进行了一项关于萎缩性胃炎、幽门螺杆菌感染及生活方式因素的病例对照研究。参与者无上消化道手术史。他们从1987年参加年度健康检查的京都府一个乡村城镇的1395名成年（35岁及以上）居民中选取。根据血清胃蛋白酶原水平诊断萎缩性胃炎：胃蛋白酶原I水平（≤70 ng/ml）及胃蛋白酶原I/胃蛋白酶原II比值（≤3.0）。幽门螺杆菌免疫球蛋白G抗体的存在表明幽门螺杆菌感染。在健康检查时，就参与者的日常生活习惯进行询问，如吸烟、饮酒情况及黄绿色蔬菜的摄入量。无条件逻辑回归分析表明，对于所有参与者，幽门螺杆菌感染与萎缩性胃炎风险显著增加相关（比值比，8.17；95%置信区间，5.63 - 11.84）；对于男性（比值比，10.91；95%置信区间，5.25 - 22.67）；对于女性（比值比，7.28；95%置信区间，4.72 - 11.22）。我们未发现生活方式因素与萎缩性胃炎之间存在统计学显著关联。
