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在干扰素α治疗期间诊断出的系统性红斑狼疮。

Systemic lupus erythematosus diagnosed during interferon alfa therapy.

作者信息

Morris L F, Lemak N A, Arnett F C, Jordon R E, Duvic M

机构信息

Department of Dermatology, University of Texas Medical School, Houston, USA.

出版信息

South Med J. 1996 Aug;89(8):810-4. doi: 10.1097/00007611-199608000-00012.

DOI:10.1097/00007611-199608000-00012
PMID:8701383
Abstract

We describe a patient who had clinical manifestations of several autoimmune disorders: Sjögren's syndrome, benign hypergammaglobulinemic purpura of Waldenström, and systemic lupus erythematosus (SLE). The SLE was diagnosed during therapy with interferon alfa. Testing for anti-Ro and anti-La antibodies was negative until the serum was diluted to eliminate a possible prozone phenomenon of antibody excess.

摘要

我们描述了一位患有多种自身免疫性疾病临床表现的患者

干燥综合征、瓦尔登斯特伦良性高球蛋白血症性紫癜和系统性红斑狼疮(SLE)。该SLE是在使用干扰素α治疗期间诊断出来的。抗Ro和抗La抗体检测一直呈阴性,直到血清被稀释以消除可能的抗体过量前带现象。

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Systemic lupus erythematosus diagnosed during interferon alfa therapy.在干扰素α治疗期间诊断出的系统性红斑狼疮。
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Enhancement of CD8T cell cytotoxicity activity by IFN-α implies alternative pathologic role in systemic lupus erythematosus.干扰素-α增强CD8⁺T细胞的细胞毒性活性意味着其在系统性红斑狼疮中具有其他病理作用。
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Broad spectrum of interferon-related nephropathies-glomerulonephritis, systemic lupus erythematosus-like syndrome and thrombotic microangiopathy: A case report and review of literature.干扰素相关肾病的广泛谱系——肾小球肾炎、系统性红斑狼疮样综合征和血栓性微血管病:一例病例报告及文献综述
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