Schäfer B W, Heizmann C W
Department of Pediatrics, University of Zurich, Switzerland.
Trends Biochem Sci. 1996 Apr;21(4):134-40. doi: 10.1016/s0968-0004(96)80167-8.
Calcium lons as second messengers control many biological processes, at least in part, via interaction with a large number of Ca(2+)-binding proteins. One class of these proteins shares a common Ca(2+)-binding motif, the EF-hand, Here, we describe some functional aspects of EF-hand proteins, which have been found recently in different cellular compartments. Novel links between EF-hand proteins, particularly S100 proteins, and specific diseases are now emerging.
钙离子作为第二信使至少部分地通过与大量钙结合蛋白相互作用来控制许多生物学过程。这类蛋白中的一类具有共同的钙结合基序，即EF手结构。在此，我们描述了EF手蛋白的一些功能方面，这些蛋白最近在不同的细胞区室中被发现。EF手蛋白，特别是S100蛋白，与特定疾病之间的新联系正在显现。
