Orihashi Ryuzo, Fujino Narumi, Mizoguchi Yoshito
Institute of Nursing Faculty of Medicine, Saga University Saga Japan.
Department of Psychiatry Faculty of Medicine, Saga University Saga Japan.
PCN Rep. 2025 Jun 5;4(2):e70130. doi: 10.1002/pcn5.70130. eCollection 2025 Jun.
The aging of the global population has made healthy aging and the extension of healthy life expectancy significant challenges for many societies. Mental health, including cognitive function, is critical to the quality of life of older adults. Oxytocin, a neuropeptide involved in social bonding and stress regulation, has been shown to exert neuroprotective effects, while S100B, a calcium-binding protein, has been linked to neuroinflammation and neurodegenerative disorders, such as Alzheimer's disease. However, the relationship between oxytocin and S100B levels during aging remains unclear. This study investigated the association between serum oxytocin and S100B levels in community-dwelling older adults.
This survey, conducted between November 2016 and September 2017 in Kurokawa-cho, Imari, Saga Prefecture, Japan, included community-dwelling older adults aged ≥65 years. Blood samples were collected to measure serum oxytocin and S100B levels using an enzyme-linked immunosorbent assay. The relationships among serum oxytocin, S100B, and cognitive function (Mini-Mental State Examination, Frontal Assessment Battery, and Clinical Dementia Rating) were analyzed using correlation and multiple regression analyses.
A total of 95 participants (25 men, 70 women; mean age: 78.03 ± 5.12 years) were analyzed. Our analysis showed that serum oxytocin levels were negatively associated with serum S100B levels even after adjusting for age, sex, years of education, and body mass index. However, no significant correlations were found between these biomarkers and overall cognitive function.
These findings suggest that the neuroprotective effects of oxytocin may influence blood S100B levels, though its direct role in cognitive function remains unclear.
全球人口老龄化使健康老龄化和延长健康预期寿命成为许多社会面临的重大挑战。心理健康，包括认知功能，对老年人的生活质量至关重要。催产素是一种参与社会联系和应激调节的神经肽，已被证明具有神经保护作用，而S100B是一种钙结合蛋白，与神经炎症和神经退行性疾病（如阿尔茨海默病）有关。然而，衰老过程中催产素与S100B水平之间的关系仍不清楚。本研究调查了社区居住老年人血清催产素与S100B水平之间的关联。
2016年１1月至2017年9月在日本佐贺县伊万里市黑川町进行的这项调查纳入了年龄≥65岁的社区居住老年人。采集血样，采用酶联免疫吸附测定法测量血清催产素和S１00B水平。使用相关性分析和多元回归分析来分析血清催产素、S100B与认知功能（简易精神状态检查表、额叶评估量表和临床痴呆评定量表）之间的关系。
共分析了95名参与者（25名男性，70名女性；平均年龄：78.03±5.12岁）。我们的分析表明，即使在调整年龄、性别、受教育年限和体重指数后，血清催产素水平仍与血清S100B水平呈负相关关系。然而，未发现这些生物标志物与整体认知功能之间存在显著相关性。
这些发现表明，催产素的神经保护作用可能会影响血液中S100B水平，尽管其在认知功能中的直接作用仍不清楚。
