HMG-CoA还原酶的生物学特性：反向调节的益处。
The biology of HMG-CoA reductase: the pros of contra-regulation.
作者信息
Hampton R, Dimster-Denk D, Rine J
机构信息
Department of Biology, University of California, San Diego, La Jolla 92093, USA.
出版信息
Trends Biochem Sci. 1996 Apr;21(4):140-5.
PMID:8701471
Abstract
Hydroxymethylglutaryl-CoA reductase (HMG-R) is a key enzyme in the mevalonate pathway, from which thousands of molecules are derived including cholesterol and prenyl moieties. The regulation of HMG-R is complex and includes feedback control, cross-regulation by independent bio-chemical processes and contra-regulation of separate isozymes. From studies in yeast, these separate modes of regulation can be considered in an integrated fashion.
摘要
羟甲基戊二酰辅酶A还原酶（HMG-R）是甲羟戊酸途径中的关键酶，该途径可衍生出数千种分子，包括胆固醇和异戊二烯基部分。HMG-R的调节很复杂，包括反馈控制、独立生化过程的交叉调节以及不同同工酶的反向调节。从酵母研究中可知，这些不同的调节模式可以综合起来考虑。
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