Diklić A, Paunović I, Batev N, Malenković V, Havelka M, Janković R
Institute of Endocrinology, University Clinical Center, Belgrade.
Acta Chir Iugosl. 1991;38(1):61-8.
Among 319 patients with Graves-Basedow disease who were operated upon in surgical department of The Institute of Endocrinology in Belgrade between 1978 and 1990, thyroid carcinoma was found in 15 cases (4.7%). In 10 patients carcinoma was suspected before operation because of the node in diffuse goiter, while in 5 patients carcinoma was found unexpectedly. Tumor was smaller than 1 sm in only one patient. Nine patients had papillary carcinoma, 4 had follicular and 2 had medullary carcinoma. One patient with medullary carcinoma had been treated previously with radioactive iodine. In 2 patients carcinoma was found in recurrent goiter after primary operation, patients with thyroid carcinoma in Graves-Basedow disease were averaging about 10 years older than other patients with Graves-Basedow disease treated surgically.
1978年至1990年间，在贝尔格莱德内分泌研究所外科接受手术的319例格雷夫斯-巴塞多病患者中，发现15例（4.7%）患有甲状腺癌。10例患者术前因弥漫性甲状腺肿中的结节而怀疑患有癌症，5例患者意外发现患有癌症。仅1例患者的肿瘤小于1厘米。9例患者为乳头状癌，4例为滤泡状癌，2例为髓样癌。1例髓样癌患者曾接受过放射性碘治疗。2例患者在初次手术后的复发性甲状腺肿中发现癌症，格雷夫斯-巴塞多病合并甲状腺癌的患者平均比接受手术治疗的其他格雷夫斯-巴塞多病患者大10岁左右。
